Methylcobalamin is one of the two coenzyme forms of vitamin B12 (the other being adenosylcobalamin). It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine.PharmacokineticsEvidence indicates methylcobalamin is utilized more efficiently than cyanocobalamin to increase levels of one of the coenzyme forms of vitamin B12. Experiments have demon-strated similar absorption of methylcobalamin following oral administration. The quantity of cobalamin detected following a small oral dose of methylcobalamin is similar to the amount following administration of cyanocobalamin; but significantly more cobalamin accumulates in liver tissue following administration of methylcobalamin. Human urinary excretion of methylcobalamin is about one-third that of a similar dose of cyanocobalamin, indicating substantially greater tissue retention.
Role of methylcobalamine in Male Infertility
In one study, methylcobalamin, at a dose of 6 mg per day for 16 weeks, improved sperm
count by 37.5 percent.
In a separate investigation, methylcobalamin, given at a dose of 1,500
micrograms per day for 4-24 weeks, resulted in sperm concentration increases in 38 percent
of cases, total sperm count increases in 54 percent of cases, and sperm motility increases in
50 percent of cases.
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